1st and only HAE treatment indicated for use in pediatrics. Learn more ►
Berinert is the only HAE treatment featuring weight-based dosing.

Learn how to calculate the correct dose of Berinert so that you can be sure that your patients are getting the optimal amount of C1-INH.

Dosing Rates and Administration Details Berinert is a lyophilized concentrate (500 IU) that requires reconstitution with 10 mL of sterile water (included). No refrigeration is required. Treatment is given as an intravenous infusion, via self-administration or by a healthcare professional.

The recommended Berinert dosage is 20 units (U) per kilogram body weight, with a recommended infusion rate of 4 mL/minute. For example, a 70-kg patient would require 1400 U, infused over 7 minutes.

Patient's weight:

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Berinert Dosage and Infusion Time:


Preparation and Reconstitution

Each Berinert kit consists of 1 carton containing 1 single-use vial of Berinert, one 10-mL vial of diluent (sterile water), 1 Mix2Vial® transfer set, and 1 alcohol swab.

The Mix2Vial transfer set enables reconstitution to occur. It automatically transfers the right amount of diluent into the Berinert vial. For step-by-step instructions on how to prepare Berinert for administration, please see the self-administration step-by-step guide, video, or full prescribing information for Berinert.

Mix2Vial is a registered trademark of Medimop Medical Projects, Ltd., a subsidiary of West Pharmaceutical Services, Inc.

Save on Co-Pays: The Berinert Co-Pay BENefit™ may cover up to $12,000 of your eligible out-of-pocket expenses per year.

Download Enrollment Form »

It is important for patients to undergo training from a healthcare professional before patients can self-administer Berinert.

Home Dosing and Administration

Important Safety Information

BERINERT®, C1 Esterase Inhibitor (Human), is a plasma-derived concentrate of C1 Esterase Inhibitor (Human), indicated for the treatment of acute abdominal, facial or laryngeal attacks of hereditary angioedema (HAE) in adult and pediatric patients. The safety and efficacy of BERINERT for prophylactic therapy have not been established.

BERINERT is contraindicated in individuals with a history of life-threatening systemic reactions to C1 esterase inhibitor preparations (including anaphylaxis).

Monitor patients for early signs of allergic or hypersensitivity reactions (including hives, generalized urticaria, chest tightness, wheezing, hypotension, and anaphylaxis). If hypersensitivity is suspected, immediately discontinue administration of BERINERT and initiate appropriate treatment. Epinephrine should be immediately available for treatment of acute severe hypersensitivity reactions.

Serious arterial and venous thromboembolic (TE) events have been reported following administration of recommended doses of C1 Esterase Inhibitor (Human) products to patients with HAE. Risk factors may include presence of an indwelling venous catheter/access device; prior history of thrombosis; underlying atherosclerosis; use of oral contraceptives or certain androgens; morbid obesity; and immobility. Weigh benefits/risks before administering to patients with known risk factors for TE events and closely monitor such patients during and after BERINERT administration. TE events also have been reported with C1 Esterase Inhibitor (Human) products when used for unapproved indications at higher than recommended doses.

Appropriately trained patients may self-administer BERINERT upon recognition of an HAE attack. Advise patients to seek medical attention immediately following selfadministration for laryngeal attacks, and to seek medical attention if progress of any attack makes them unable to properly prepare or administer dose of BERINERT.

BERINERT is derived from human plasma. The risk of transmission of infectious agents, including viruses and theoretically, the agents of Creutzfeldt-Jakob Disease (CJD) and its variant form (vCJD), cannot be completely eliminated.

The most serious adverse reaction reported in subjects who received BERINERT in clinical studies was an increase in severity of pain associated with HAE. Dysgeusia was the most common adverse reaction reported in over 4% of subjects and more frequently than in the placebo group.

BERINERT has not been evaluated in pregnant women or nursing mothers, and should be used only if clearly needed. In clinical trials, the half-life of BERINERT was shorter and clearance was faster in children than in adults; the clinical implication of this difference is not known.

Please see full prescribing information for BERINERT, including the patient product information.

CSL Behring
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