1st and only HAE treatment indicated for use in pediatrics. Learn more ►
Berinert is the only HAE treatment featuring weight-based dosing.

Learn how to calculate the correct dose of Berinert so that you can be sure that your patients are getting the optimal amount of C1-INH.

Patient Self-Administration Training Before your patients self-administer Berinert, it is important that they undergo training from a healthcare professional.

It is also vital for patients to recognize symptoms of their HAE attacks, learn how to monitor their symptoms, and to treat their attacks. B.E.N. can help arrange training for your patients through qualified specialty pharmacy providers, and can provide training materials as well.

If a patient self-administers to treat a laryngeal attack, he or she should immediately seek medical attention afterward.

Self-Administration Slide Show

Instructional Self-Administration Video

*Peer supporters are not healthcare professionals or medical experts. For medical questions, patients should contact their physicians.

Helpful resources, links, and downloads provided to healthcare providers whose patients use Berinert therapy.

Home Dosing and Administration Self-Administration Training
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Important Safety Information

BERINERT®, C1 Esterase Inhibitor (Human), is a plasma-derived concentrate of C1 Esterase Inhibitor (Human), indicated for the treatment of acute abdominal, facial or laryngeal attacks of hereditary angioedema (HAE) in adult and pediatric patients. The safety and efficacy of BERINERT for prophylactic therapy have not been established.

BERINERT is contraindicated in individuals with a history of life-threatening systemic reactions to C1 esterase inhibitor preparations (including anaphylaxis).

Monitor patients for early signs of allergic or hypersensitivity reactions (including hives, generalized urticaria, chest tightness, wheezing, hypotension, and anaphylaxis). If hypersensitivity is suspected, immediately discontinue administration of BERINERT and initiate appropriate treatment. Epinephrine should be immediately available for treatment of acute severe hypersensitivity reactions.

Serious arterial and venous thromboembolic (TE) events have been reported following administration of recommended doses of C1 Esterase Inhibitor (Human) products to patients with HAE. Risk factors may include presence of an indwelling venous catheter/access device; prior history of thrombosis; underlying atherosclerosis; use of oral contraceptives or certain androgens; morbid obesity; and immobility. Weigh benefits/risks before administering to patients with known risk factors for TE events and closely monitor such patients during and after BERINERT administration. TE events also have been reported with C1 Esterase Inhibitor (Human) products when used for unapproved indications at higher than recommended doses.

Appropriately trained patients may self-administer BERINERT upon recognition of an HAE attack. Advise patients to seek medical attention immediately following selfadministration for laryngeal attacks, and to seek medical attention if progress of any attack makes them unable to properly prepare or administer dose of BERINERT.

BERINERT is derived from human plasma. The risk of transmission of infectious agents, including viruses and theoretically, the agents of Creutzfeldt-Jakob Disease (CJD) and its variant form (vCJD), cannot be completely eliminated.

The most serious adverse reaction reported in subjects who received BERINERT in clinical studies was an increase in severity of pain associated with HAE. Dysgeusia was the most common adverse reaction reported in over 4% of subjects and more frequently than in the placebo group.

BERINERT has not been evaluated in pregnant women or nursing mothers, and should be used only if clearly needed. In clinical trials, the half-life of BERINERT was shorter and clearance was faster in children than in adults; the clinical implication of this difference is not known.

Please see full prescribing information for BERINERT, including the patient product information.

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© 2017 CSL Behring. The product information presented on this site is intended for US residents only. BRN/03-13-0059(1)d