On-demand therapy that you can self-administer gives you the power to react quickly to the first signs of an HAE attack, wherever you happen to be. The sooner you treat with BERINERT, the faster you will experience relief. Treating quickly is especially important if you experience a laryngeal attack, as it can be life threatening.
BERINERT is the only on-demand C1-INH approved for self-administration to treat acute abdominal, facial, or laryngeal attacks of HAE in adults and children.
IV infusion of BERINERT delivers the active ingredient—C1-INH—directly into your bloodstream so it can go to work fast, restoring your body’s ability to stop the swelling.
Following setup, BERINERT takes about 7 to 8 minutes* to self-administer for an average-sized adult.†
*Based on an infusion rate of 4 mL per minute.
† 70—80 kg (154—176 lb).
Your BERINERT dose is calculated by weight. That means you get an individualized amount of medicine—for your body.
And because BERINERT is given on demand for acute attacks, you take it only when you need it.
The recommended dose is 20 IU/kg body weight.
BERINERT is an IV infusion that you can learn to self-administer at home or anywhere that’s convenient. In fact, a study showed that 95% of BERINERT infusions were given outside of healthcare settings.
Use these materials in combination with self-administration training from a healthcare provider. Never attempt to self-administer BERINERT unless you’ve been taught to do so by a healthcare provider.
Watch each step of preparing and administering BERINERT in this video.
Gather your supplies
Step 1. Inspect both vials
Step 2. Wash your hands and clean surface
Hint: Use your Self-Administration Mat, which is designed to help you organize your supplies.
Step 3. Open the Mix2Vial® transfer set
Step 4. Sanitize the water vial and connect
Hint: The blue end locks onto the water vial (easy to remember: “blue” for water).
Step 5. Remove the Mix2Vial® cup
Step 6. Connect the water vial and Berinert vial
Step 7. Dissolve Berinert powder
Step 8. Open the Mix2Vial® transfer set
Step 9. Inspect the solution and draw it into a syringe
Repeat if necessary
Read before infusing
Please note that there are limited data on the use of this medicinal product in home or by self-administration. Your prescribing physician may decide that Berinert can be self-administered by a patient at home or by another nonhealthcare professional, such as a family member. Before Berinert can be safely and effectively administered at home, the person charged with infusing must have the necessary skills. Please do not try to self-administer unless you have received specific training and approval from your prescribing physician.
If you will be infusing at home, please follow the instructions for properly storing Berinert. You can find them in the package insert (prescribing information). Your prescribing physician will let you know when and in what dose to infuse Berinert. Depending on your dose, you might have to infuse several vials.
Seek immediate emergency medical treatment if you cannot enter a vein or if your attack has progressed to a point where you are unable to successfully reconstitute or administer Berinert. Contact your physician or seek emergency care if the medicine does not work or if you experience adverse reactions.
After self-administering for laryngeal attacks of HAE, seek immediate medical treatment. Inform your physician if you administer for abdominal attack of HAE, particularly if the medication does not appear to be effective, as other causes might need to be ruled out.
Gather your supplies
Inspect vials and sanitize
Hint: Use your Self-Administration Mat, which is designed to help organize your supplies.
Prepare the syringe for self-administration
Step 1. Prime (fill) the infusion set
Step 2. Prepare the infusion site
Step 3. Insert needle
Step 4. Check needle for proper placement
Step 5. Start infusion
Step 6. Remove the needle
Step 7. Cover the infusion site and clean up
Step 8. Record your infusion details