HAE is often misdiagnosed because the symptoms mimic those of several common conditions, including allergic angioedema and GI problems. But HAE is not an allergy. It is a rare, inherited disease that, in most cases, is caused by C1 esterase inhibitor (C1-INH) deficiency, and can be fatal if not properly treated.
It’s important to determine the difference between allergic angioedema, GI problems, and HAE because the pathophysiology and the treatment of the diseases are different. HAE patients are often subjected to nonessential medical procedures, such as unnecessary surgeries, or ineffective treatments, such as antihistamines. HAE should be suspected when a patient presents with a history of recurrent angioedema, especially if hives are absent.10
Select Yes or No for each question and click See result.
1. Unexplained edema?
2.Asymmetric swelling attacks to the extremities?
3.Unexplained abdominal pain?
5.Family history of similar episodes?
6.Symptoms (eg, tingling or nausea) signaling the onset of an attack?12
7.Antihistamines, epinephrine, or corticosteroids provide little relief?4
8.Angioedema without urticaria?