Diagnosing HAE

HAE is often misdiagnosed because the symptoms mimic those of several common conditions, including allergic angioedema and GI problems. But HAE is not an allergy. It is a rare, inherited disease that, in most cases, is caused by C1 esterase inhibitor (C1-INH) deficiency, and can be fatal if not properly treated.

Undiagnosed HAE can take a toll on patients

It’s important to determine the difference between allergic angioedema, GI problems, and HAE because the pathophysiology and the treatment of the diseases are different. HAE patients are often subjected to nonessential medical procedures, such as unnecessary surgeries, or ineffective treatments, such as antihistamines. HAE should be suspected when a patient presents with a history of recurrent angioedema, especially if hives are absent.10

Differentiate with 8

Consider 8 questions to identify a potential HAE patient11

Select Yes or No for each question and click See result.

1. Unexplained edema?

2.Asymmetric swelling attacks to the extremities?

3.Unexplained abdominal pain?

4.Recurrent attacks?

5.Family history of similar episodes?

6.Symptoms (eg, tingling or nausea) signaling the onset of an attack?12

7.Antihistamines, epinephrine, or corticosteroids provide little relief?4

8.Angioedema without urticaria?

Differentiate with 8 PDF

Differentiate with 8

Download 8 simple questions you can ask your patients to help determine if further testing is needed.

Download PDF

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