Individualized, weight-based dosing and self-administration

During an HAE attack, patients treating with on-demand therapy need the right dose at the first sign of an attack. With BERINERT, patients can self-administer an appropriate dose when and where they need to.

The 1st and only plasma-derived on-demand HAE therapy with weight-based dosing

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BERINERT delivers an individualized amount of C1-INH for every patient.

  • The recommended dosage is 20 IU per kilogram of body weight with an infusion rate of 4 mL/min
  • Doses lower than 20 IU/kg body weight should not be administered

Time to onset of symptom relief (hours)1

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BERINERT dosing example

  • BERINERT is supplied in a single-use vial of 500 IU to be reconstituted with 10 mL sterile water for injection
  • Administer BERINERT at a dose of 20 International Units (IU) per kg body weight by intravenous injection. Doses lower than 20 IU/ 20 IU/kg body weight should not be administered
  • Examples below administered at 4 mL per minute
Patient weight Units Minutes # of vials
20 kg/44 lb 400 IU 2 min 0.8 vial
45 kg/99 lb 900 IU 4.5 min 1.8 vials
70 kg/154 lb 1400 IU 7 min 2.8 vials

Quickly calculate the recommended dose for your patient by entering their body weight.

Dosing calculator

Preparation and reconstitution

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Each BERINERT kit consists of:

  • One single-dose vial of BERINERT
  • One 10 mL vial of diluent (Sterile Water for Injection, USP)
  • One Mix2Vial® filter transfer set
  • 10 mL silicone-free syringe
  • IV set and butterfly needle
  • Alcohol swab
View, download, or watch step-by-step instructions on how to reconstitute and administer BERINERT here, or view the full prescribing information for BERINERT.

Empower your patients to self-administer at the first sign of an HAE attack

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The treatment works on demand, so it’s used only when patients have an acute abdominal, facial, or laryngeal attack—not to prevent an attack.

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Patients can infuse on their own or with help from a caregiver after receiving proper training from a healthcare professional.

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Learning how to self-administer can be crucial in the event of a life-threatening laryngeal HAE attack.

Following self-administration of BERINERT for laryngeal HAE attacks, advise patients to immediately seek medical attention.

Self-administration Guide
Download and keep the Self-administration Guide for when you or your patients need it.
Download PDF

Self-administration video
Watch step-by-step instructions on how to self-administer BERINERT by intravenous infusion.
Watch video

Reference: 1. Bernstein JA, Machnig T, Keinecke H-O, Whelan GJ, Craig TJ. The effect of weight on the efficacy and safety of C1 esterase inhibitor concentrate for the treatment of acute hereditary angioedema. Clin Ther. 2014;36(4):518-525.

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